Yes, sometimes. But the reason is rarely what people assume, and the distinction matters because the wrong conclusion leads to abandoning something that was working.
The format is not usually the issue. What is being sealed against the skin for fifteen minutes might be.
Why occlusion itself is not the problem
The intuitive worry is that covering the skin traps oil and sweat, creating exactly the conditions congestion needs. Fifteen minutes under a sealed layer sounds like it should be a problem for skin already prone to blockage.
In practice it rarely is. Congestion forms over days as sebum and dead cells accumulate inside a follicle, not in a quarter of an hour. Occlusion at that timescale primarily does one thing, it stops the formula evaporating and forces it into the skin instead.
Prolonged occlusion is a genuine issue, which is why sleeping in a mask is a bad idea and why heavy occlusive balms can congest skin over time. A fifteen-minute treatment is a different situation entirely.
What actually causes the reaction
Three things, in rough order of likelihood.
Heavy oils and waxes in the formula. Occlusion works both ways, it drives actives in and it also drives everything else in. A formula containing heavy comedogenic oils delivers those more effectively under a mask than it would rubbed in, which is the one situation where the format genuinely amplifies a problem.
Fragrance. Irritation causes inflammation, inflammation is part of how blemishes form, and a sealed layer increases how much of a fragranced formula reaches the skin. This can produce blemishes without any obvious reaction, which makes it hard to identify.
A compromised barrier underneath. If the skin was already over-exfoliated or stripped, it is more permeable and more reactive to everything, including formulas that would normally be fine. In this case the mask is revealing a problem rather than causing one.

Purging is a real thing, and also an overused excuse
Worth separating honestly, because the term gets used to explain away genuine reactions.
Purging is real when a product accelerates cell turnover. Congestion that was already forming beneath the surface reaches the top faster than it otherwise would, appearing as a cluster of blemishes in the first few weeks. It happens with acids and retinoids, and it settles.
Three things distinguish it from a reaction. Location, purging appears where you normally get congestion, since it is bringing existing blockages up. Timing, it starts within the first week or two and resolves within four to six. And speed, purged blemishes come and go faster than usual rather than lingering.
What is not purging: new blemishes in areas you do not normally break out, anything lasting beyond six weeks, or any reaction to a product with no exfoliating or turnover-accelerating ingredient. A hydrating mask cannot cause purging, because there is no mechanism for it. If a hydrating product is causing blemishes, that is a reaction.
What to look for in a formula
The same principles as reading any ingredient list, with congestion-specific priorities.
Position matters more than presence. An oil listed twenty-fourth is present in trace amounts, an oil listed second is the base of the formula. The same ingredient can be fine in one product and a problem in another purely on concentration.
Fragrance is the easiest single thing to eliminate, and worth doing first if you are troubleshooting rather than changing several variables at once.
Lightweight, water-binding formulas are the safest category. Pink Cactus and Camellia are oil-based but built around lighter, fast-absorbing plant oils rather than heavy occlusives, and After Party carries Niacinamide, which supports the barrier and helps regulate oil production.
The mistake that follows a breakout
Almost universally, people respond by stripping. Stronger cleanser, more exfoliation, skipping moisturiser entirely.
This is the same cycle that makes blemishes worse. A stripped barrier is more permeable and more reactive, and skin frequently overproduces oil to compensate for what was removed. The next product then causes a reaction that would not have occurred on intact skin, which appears to confirm the original conclusion.
The more useful response is to stop, let the barrier recover for two weeks with nothing active, and reintroduce one thing at a time.

How to introduce a new mask sensibly
Patch test first, on the jaw rather than the inner arm. Facial skin behaves differently from arm skin, and the jaw is close enough to be representative while being easy to cover.
Introduce one new product at a time and leave two weeks between additions. Reactions frequently appear on the fourth or fifth use rather than the first, so a single trial proves less than people assume.
Once weekly at first rather than twice, and only increase if the skin is comfortable.
If you do react, stop and wait rather than adding something to fix it. Most mild reactions settle within seven to ten days once the trigger is removed, and adding more products makes identifying the cause impossible.